5 Long Term Side Effect of Biologics Expert wants you to know in Inflammatory Bowel Disease

One of the most well-known risks associated with biologics is an increased susceptibility to infections. Biologics work by suppressing the immune system, which can make it more difficult for the body to fight off infections. In particular, patients taking biologics are at higher risk for serious bacterial and viral infections, such as tuberculosis and hepatitis B. For this reason, patients receiving biologics should be screened for infections before starting treatment and should be monitored closely for signs of infection during treatment.

Another potential long-term side effect of biologics is an increased risk of certain types of cancer. While the overall risk is still considered low, studies have shown that patients taking biologics may be at slightly higher risk for lymphoma and non-melanoma skin cancers. However, it is important to note that the increased risk appears to be primarily associated with long-term use of biologics, and the benefits of these drugs in controlling inflammation and preventing complications of IBD generally outweigh the potential risks.

In addition to infections and cancer, there are other potential long-term side effects of biologics that are still being studied. For example, some studies have suggested that biologics may increase the risk of heart disease, while others have found no significant association. There have also been reports of rare side effects, such as drug-induced lupus and neurological disorders. While these risks are considered to be very low, patients and healthcare providers should be aware of the potential for these side effects and monitor for any new symptoms or changes in health status. It is important to note that the risks associated with biologics must be weighed against the potential benefits.

Biologics have been shown to be highly effective in reducing inflammation and improving quality of life for many patients with IBD, and in some cases, they may be the best option for controlling symptoms and preventing complications. Patients considering biologic therapy should have a thorough discussion with their healthcare provider about the potential risks and benefits, and should be monitored closely during treatment.

In conclusion, while biologics can be effective in treating IBD, they do carry potential long-term side effects that patients and healthcare providers should be aware of. It is important to weigh the risks against the benefits and to closely monitor patients for any signs of infection, cancer, or other potential side effects. With proper monitoring and management, biologic therapy can be a valuable tool in the treatment of IBD. Speak to our inflammatory bowel disease expert to know more about your treatment options.

Reference:

• Crohn’s & Colitis Foundation – Biologic Drugs Mayo Clinic – Biologic Drugs for Crohn’s Disease: Possible Side Effects
• American Gastroenterological Association – Biologics in IBD: What You Need to Know